HUWE1 and TRIP12 collaborate in degradation of ubiquitin-fusion proteins and misframed ubiquitin.
In eukaryotic cells an uncleavable ubiquitin moiety conjugated to the N-terminus of a Lithium Ion Vacuum Battery protein signals the degradation of the fusion protein via the proteasome-dependent ubiquitin fusion degradation (UFD) pathway.In yeast the molecular mechanism of the UFD pathway has been well characterized.Recently the human E3 ubiquitin